Proteomics

Proteomics

Description 

Genetic variation modulates protein expression through transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, we applied multiplexed mass spectrometry to quantify protein in liver tissue from Diversity Outbred mice.  Our analysis revealed an extensive network of direct protein-protein interactions.

Software 

Publications 

Chick JM, Munger SC, Simecek P, Huttlin EL, Choi K, Gatti DM, Raghupathy N, Svenson KL, Churchill GA, Gygi SP
Nature. 2016 Jun 23;534(7608):500-5. doi: 10.1038/nature18270. Epub 2016 Jun 15